Adult stem cell deficits drive Slc29a3 disorders in mice
Identifieur interne : 000B05 ( Main/Exploration ); précédent : 000B04; suivant : 000B06Adult stem cell deficits drive Slc29a3 disorders in mice
Auteurs : Sreenath Nair [États-Unis] ; Anne M. Strohecker [États-Unis] ; Avinash K. Persaud [États-Unis] ; Bhawana Bissa [États-Unis] ; Shanmugam Muruganandan [États-Unis] ; Craig Mcelroy [États-Unis] ; Rakesh Pathak [États-Unis] ; Michelle Williams [États-Unis] ; Radhika Raj [États-Unis] ; Amal Kaddoumi [États-Unis] ; Alex Sparreboom [États-Unis] ; Aaron M. Beedle [États-Unis] ; Rajgopal Govindarajan [États-Unis]Source :
- Nature Communications [ 2041-1723 ] ; 2019.
Abstract
Mutations exclusively in equilibrative nucleoside transporter 3 (ENT3), the only intracellular nucleoside transporter within the solute carrier 29 (
Url:
DOI: 10.1038/s41467-019-10925-3
PubMed: 31270333
PubMed Central: 6610100
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000144
- to stream Pmc, to step Curation: 000144
- to stream Pmc, to step Checkpoint: 000A30
- to stream Ncbi, to step Merge: 000766
- to stream Ncbi, to step Curation: 000766
- to stream Ncbi, to step Checkpoint: 000766
- to stream Main, to step Merge: 000B05
- to stream Main, to step Curation: 000B05
Le document en format XML
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Strohecker</name><affiliation wicri:level="2"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Department of Cancer Biology and Genetics, College of Medicine,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Molecular Biology and Cancer Genetics, Ohio State University Comprehensive Cancer Center,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Persaud, Avinash K" sort="Persaud, Avinash K" uniqKey="Persaud A" first="Avinash K." last="Persaud">Avinash K. Persaud</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Muruganandan, Shanmugam" sort="Muruganandan, Shanmugam" uniqKey="Muruganandan S" first="Shanmugam" last="Muruganandan">Shanmugam Muruganandan</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Mcelroy, Craig" sort="Mcelroy, Craig" uniqKey="Mcelroy C" first="Craig" last="Mcelroy">Craig Mcelroy</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Pathak, Rakesh" sort="Pathak, Rakesh" uniqKey="Pathak R" first="Rakesh" last="Pathak">Rakesh Pathak</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Williams, Michelle" sort="Williams, Michelle" uniqKey="Williams M" first="Michelle" last="Williams">Michelle Williams</name><affiliation wicri:level="2"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Department of Radiology,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Raj, Radhika" sort="Raj, Radhika" uniqKey="Raj R" first="Radhika" last="Raj">Radhika Raj</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Kaddoumi, Amal" sort="Kaddoumi, Amal" uniqKey="Kaddoumi A" first="Amal" last="Kaddoumi">Amal Kaddoumi</name><affiliation wicri:level="2"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2297 8753</institution-id><institution-id institution-id-type="GRID">grid.252546.2</institution-id><institution>Department of Drug Discovery and Development, Harrison School of Pharmacy,</institution><institution>Auburn University,</institution></institution-wrap>Auburn, AL 36849 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Alabama</region></placeName><wicri:cityArea>Auburn</wicri:cityArea></affiliation></author><author><name sortKey="Sparreboom, Alex" sort="Sparreboom, Alex" uniqKey="Sparreboom A" first="Alex" last="Sparreboom">Alex Sparreboom</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author><author><name sortKey="Beedle, Aaron M" sort="Beedle, Aaron M" uniqKey="Beedle A" first="Aaron M." last="Beedle">Aaron M. Beedle</name><affiliation wicri:level="2"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2164 4508</institution-id><institution-id institution-id-type="GRID">grid.264260.4</institution-id><institution>Department of Pharmaceutical Sciences,</institution><institution>SUNY Binghamton University,</institution></institution-wrap>Binghamton, NY 13902 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Binghamton</wicri:cityArea></affiliation></author><author><name sortKey="Govindarajan, Rajgopal" sort="Govindarajan, Rajgopal" uniqKey="Govindarajan R" first="Rajgopal" last="Govindarajan">Rajgopal Govindarajan</name><affiliation wicri:level="2"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Division of Pharmaceutics and Pharmaceutical Chemistry, College of Pharmacy,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2285 7943</institution-id><institution-id institution-id-type="GRID">grid.261331.4</institution-id><institution>Translational Therapeutics, Ohio State University Comprehensive Cancer Center,</institution><institution>Ohio State University,</institution></institution-wrap>Columbus, OH 43210 USA</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea>Columbus</wicri:cityArea></affiliation></author></analytic><series><title level="j">Nature Communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Mutations exclusively in equilibrative nucleoside transporter 3 (ENT3), the only intracellular nucleoside transporter within the solute carrier 29 (<italic>SLC29</italic>) gene family, cause an expanding spectrum of human genetic disorders (e.g., H syndrome, PHID syndrome, and SHML/RDD syndrome). Here, we identify adult stem cell deficits that drive ENT3-related abnormalities in mice. ENT3 deficiency alters hematopoietic and mesenchymal stem cell fates; the former leads to stem cell exhaustion, and the latter leads to breaches of mesodermal tissue integrity. The molecular pathogenesis stems from the loss of lysosomal adenosine transport, which impedes autophagy-regulated stem cell differentiation programs via misregulation of the AMPK-mTOR-ULK axis. Furthermore, mass spectrometry-based metabolomics and bioenergetics studies identify defects in fatty acid utilization, and alterations in mitochondrial bioenergetics can additionally propel stem cell deficits. Genetic, pharmacologic and stem cell interventions ameliorate ENT3-disease pathologies and extend the lifespan of ENT3-deficient mice. These findings delineate a primary pathogenic basis for the development of ENT3 spectrum disorders and offer critical mechanistic insights into treating human ENT3-related disorders.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rossbach, Hc" uniqKey="Rossbach H">HC Rossbach</name></author><author><name sortKey="Dalence, C" uniqKey="Dalence C">C Dalence</name></author><author><name sortKey="Wynn, T" uniqKey="Wynn T">T Wynn</name></author><author><name sortKey="Tebbi, C" uniqKey="Tebbi C">C Tebbi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zur Stadt, U" uniqKey="Zur Stadt U">U Zur Stadt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Prendiville, J" uniqKey="Prendiville J">J Prendiville</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hussain, K" uniqKey="Hussain K">K Hussain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molho Pessach, V" uniqKey="Molho Pessach V">V Molho-Pessach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cliffe, St" uniqKey="Cliffe S">ST Cliffe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Nv" uniqKey="Morgan N">NV Morgan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Priya, Tp" uniqKey="Priya T">TP Priya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramot, Y" uniqKey="Ramot Y">Y Ramot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Campeau, Pm" uniqKey="Campeau P">PM Campeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Colmenero, I" uniqKey="Colmenero I">I Colmenero</name></author><author><name sortKey="Molho Pessach, V" uniqKey="Molho Pessach V">V Molho-Pessach</name></author><author><name sortKey="Torrelo, A" uniqKey="Torrelo A">A Torrelo</name></author><author><name sortKey="Zlotogorski, A" uniqKey="Zlotogorski A">A Zlotogorski</name></author><author><name sortKey="Requena, L" uniqKey="Requena L">L Requena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farooq, M" uniqKey="Farooq M">M Farooq</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jesus, J" uniqKey="De Jesus J">J de Jesus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Elbarbary, Ns" uniqKey="Elbarbary N">NS Elbarbary</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Molho Pessach, V" uniqKey="Molho Pessach V">V Molho-Pessach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Haggar, M" uniqKey="Al Haggar M">M Al-Haggar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Young, Jd" uniqKey="Young J">JD Young</name></author><author><name sortKey="Yao, Sy" uniqKey="Yao S">SY Yao</name></author><author><name sortKey="Baldwin, Jm" uniqKey="Baldwin J">JM Baldwin</name></author><author><name sortKey="Cass, Ce" uniqKey="Cass C">CE Cass</name></author><author><name sortKey="Baldwin, Sa" uniqKey="Baldwin S">SA Baldwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, N" uniqKey="Kang N">N Kang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldwin, Sa" uniqKey="Baldwin S">SA Baldwin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Govindarajan, R" uniqKey="Govindarajan R">R Govindarajan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, Cl" uniqKey="Hsu C">CL Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahman, Md Fazlur" uniqKey="Rahman M">Md Fazlur Rahman</name></author><author><name sortKey="Askwith, Candice" uniqKey="Askwith C">Candice Askwith</name></author><author><name sortKey="Govindarajan, Rajgopal" uniqKey="Govindarajan R">Rajgopal Govindarajan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, Anusha" uniqKey="Singh A">Anusha Singh</name></author><author><name sortKey="Govindarajan, Rajgopal" uniqKey="Govindarajan R">Rajgopal Govindarajan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolze, A" uniqKey="Bolze A">A Bolze</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Melki, I" uniqKey="Melki I">I Melki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biteau, B" uniqKey="Biteau B">B Biteau</name></author><author><name sortKey="Hochmuth, Ce" uniqKey="Hochmuth C">CE Hochmuth</name></author><author><name sortKey="Jasper, H" uniqKey="Jasper H">H Jasper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kaufman, Ds" uniqKey="Kaufman D">DS Kaufman</name></author><author><name sortKey="Hanson, Et" uniqKey="Hanson E">ET Hanson</name></author><author><name sortKey="Lewis, Rl" uniqKey="Lewis R">RL Lewis</name></author><author><name sortKey="Auerbach, R" uniqKey="Auerbach R">R Auerbach</name></author><author><name sortKey="Thomson, Ja" uniqKey="Thomson J">JA Thomson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, P" uniqKey="Zhang P">P Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, L" uniqKey="Guo L">L Guo</name></author><author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y Zhou</name></author><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Han, J" uniqKey="Han J">J Han</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Prat, L" uniqKey="Garcia Prat L">L Garcia-Prat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deter, Rl" uniqKey="Deter R">RL Deter</name></author><author><name sortKey="Baudhuin, P" uniqKey="Baudhuin P">P Baudhuin</name></author><author><name sortKey="De Duve, C" uniqKey="De Duve C">C De Duve</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M Komatsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortensen, M" uniqKey="Mortensen M">M Mortensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mortensen, M" uniqKey="Mortensen M">M Mortensen</name></author><author><name sortKey="Watson, As" uniqKey="Watson A">AS Watson</name></author><author><name sortKey="Simon, Ak" uniqKey="Simon A">AK Simon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vessoni, At" uniqKey="Vessoni A">AT Vessoni</name></author><author><name sortKey="Muotri, Ar" uniqKey="Muotri A">AR Muotri</name></author><author><name sortKey="Okamoto, Ok" uniqKey="Okamoto O">OK Okamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Yc" uniqKey="Kim Y">YC Kim</name></author><author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name></author><author><name sortKey="Codogno, P" uniqKey="Codogno P">P Codogno</name></author><author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pan, H" uniqKey="Pan H">H Pan</name></author><author><name sortKey="Cai, N" uniqKey="Cai N">N Cai</name></author><author><name sortKey="Li, M" uniqKey="Li M">M Li</name></author><author><name sortKey="Liu, Gh" uniqKey="Liu G">GH Liu</name></author><author><name sortKey="Izpisua Belmonte, Jc" uniqKey="Izpisua Belmonte J">JC Izpisua Belmonte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Srivastava, Ra" uniqKey="Srivastava R">RA Srivastava</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laplante, M" uniqKey="Laplante M">M Laplante</name></author><author><name sortKey="Sabatini, Dm" uniqKey="Sabatini D">DM Sabatini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, K" uniqKey="Ito K">K Ito</name></author><author><name sortKey="Suda, T" uniqKey="Suda T">T Suda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hay, N" uniqKey="Hay N">N Hay</name></author><author><name sortKey="Sonenberg, N" uniqKey="Sonenberg N">N Sonenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hara, K" uniqKey="Hara K">K Hara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, J" uniqKey="Kim J">J Kim</name></author><author><name sortKey="Kundu, M" uniqKey="Kundu M">M Kundu</name></author><author><name sortKey="Viollet, B" uniqKey="Viollet B">B Viollet</name></author><author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Viollet, B" uniqKey="Viollet B">B Viollet</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Singh, R" uniqKey="Singh R">R Singh</name></author><author><name sortKey="Cuervo, Am" uniqKey="Cuervo A">AM Cuervo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Piemontese, M" uniqKey="Piemontese M">M Piemontese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jahreiss, L" uniqKey="Jahreiss L">L Jahreiss</name></author><author><name sortKey="Menzies, Fm" uniqKey="Menzies F">FM Menzies</name></author><author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muruganandan, S" uniqKey="Muruganandan S">S Muruganandan</name></author><author><name sortKey="Dranse, Hj" uniqKey="Dranse H">HJ Dranse</name></author><author><name sortKey="Rourke, Jl" uniqKey="Rourke J">JL Rourke</name></author><author><name sortKey="Mcmullen, Nm" uniqKey="Mcmullen N">NM McMullen</name></author><author><name sortKey="Sinal, Cj" uniqKey="Sinal C">CJ Sinal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pronk, Cj" uniqKey="Pronk C">CJ Pronk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adolfsson, J" uniqKey="Adolfsson J">J Adolfsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muruganandan, S" uniqKey="Muruganandan S">S Muruganandan</name></author><author><name sortKey="Govindarajan, R" uniqKey="Govindarajan R">R Govindarajan</name></author><author><name sortKey="Mcmullen, Nm" uniqKey="Mcmullen N">NM McMullen</name></author><author><name sortKey="Sinal, Cj" uniqKey="Sinal C">CJ Sinal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muruganandan, S" uniqKey="Muruganandan S">S Muruganandan</name></author><author><name sortKey="Roman, Aa" uniqKey="Roman A">AA Roman</name></author><author><name sortKey="Sinal, Cj" uniqKey="Sinal C">CJ Sinal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, K" uniqKey="Yamada K">K Yamada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiqing, C" uniqKey="Jiqing C">C Jiqing</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Miller, Cl" uniqKey="Miller C">CL Miller</name></author><author><name sortKey="Lai, B" uniqKey="Lai B">B Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takigami, H" uniqKey="Takigami H">H Takigami</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wenzel, J" uniqKey="Wenzel J">J Wenzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tinsley, Fc" uniqKey="Tinsley F">FC Tinsley</name></author><author><name sortKey="Taicher, Gz" uniqKey="Taicher G">GZ Taicher</name></author><author><name sortKey="Heiman, Ml" uniqKey="Heiman M">ML Heiman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Sm" uniqKey="Park S">SM Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Ibanez, J" uniqKey="Lopez Ibanez J">J Lopez-Ibanez</name></author><author><name sortKey="Pazos, F" uniqKey="Pazos F">F Pazos</name></author><author><name sortKey="Chagoyen, M" uniqKey="Chagoyen M">M Chagoyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xia, J" uniqKey="Xia J">J Xia</name></author><author><name sortKey="Psychogios, N" uniqKey="Psychogios N">N Psychogios</name></author><author><name sortKey="Young, N" uniqKey="Young N">N Young</name></author><author><name sortKey="Wishart, Ds" uniqKey="Wishart D">DS Wishart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sergushichev, Aa" uniqKey="Sergushichev A">AA Sergushichev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yamada, T" uniqKey="Yamada T">T Yamada</name></author><author><name sortKey="Letunic, I" uniqKey="Letunic I">I Letunic</name></author><author><name sortKey="Okuda, S" uniqKey="Okuda S">S Okuda</name></author><author><name sortKey="Kanehisa, M" uniqKey="Kanehisa M">M Kanehisa</name></author><author><name sortKey="Bork, P" uniqKey="Bork P">P Bork</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sartor, Ma" uniqKey="Sartor M">MA Sartor</name></author><author><name sortKey="Leikauf, Gd" uniqKey="Leikauf G">GD Leikauf</name></author><author><name sortKey="Medvedovic, M" uniqKey="Medvedovic M">M Medvedovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmittgen, Td" uniqKey="Schmittgen T">TD Schmittgen</name></author><author><name sortKey="Livak, Kj" uniqKey="Livak K">KJ Livak</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Alabama</li><li>Ohio</li><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="Ohio"><name sortKey="Nair, Sreenath" sort="Nair, Sreenath" uniqKey="Nair S" first="Sreenath" last="Nair">Sreenath Nair</name></region><name sortKey="Beedle, Aaron M" sort="Beedle, Aaron M" uniqKey="Beedle A" first="Aaron M." last="Beedle">Aaron M. Beedle</name><name sortKey="Bissa, Bhawana" sort="Bissa, Bhawana" uniqKey="Bissa B" first="Bhawana" last="Bissa">Bhawana Bissa</name><name sortKey="Govindarajan, Rajgopal" sort="Govindarajan, Rajgopal" uniqKey="Govindarajan R" first="Rajgopal" last="Govindarajan">Rajgopal Govindarajan</name><name sortKey="Govindarajan, Rajgopal" sort="Govindarajan, Rajgopal" uniqKey="Govindarajan R" first="Rajgopal" last="Govindarajan">Rajgopal Govindarajan</name><name sortKey="Kaddoumi, Amal" sort="Kaddoumi, Amal" uniqKey="Kaddoumi A" first="Amal" last="Kaddoumi">Amal Kaddoumi</name><name sortKey="Mcelroy, Craig" sort="Mcelroy, Craig" uniqKey="Mcelroy C" first="Craig" last="Mcelroy">Craig Mcelroy</name><name sortKey="Muruganandan, Shanmugam" sort="Muruganandan, Shanmugam" uniqKey="Muruganandan S" first="Shanmugam" last="Muruganandan">Shanmugam Muruganandan</name><name sortKey="Pathak, Rakesh" sort="Pathak, Rakesh" uniqKey="Pathak R" first="Rakesh" last="Pathak">Rakesh Pathak</name><name sortKey="Persaud, Avinash K" sort="Persaud, Avinash K" uniqKey="Persaud A" first="Avinash K." last="Persaud">Avinash K. Persaud</name><name sortKey="Raj, Radhika" sort="Raj, Radhika" uniqKey="Raj R" first="Radhika" last="Raj">Radhika Raj</name><name sortKey="Sparreboom, Alex" sort="Sparreboom, Alex" uniqKey="Sparreboom A" first="Alex" last="Sparreboom">Alex Sparreboom</name><name sortKey="Strohecker, Anne M" sort="Strohecker, Anne M" uniqKey="Strohecker A" first="Anne M." last="Strohecker">Anne M. Strohecker</name><name sortKey="Strohecker, Anne M" sort="Strohecker, Anne M" uniqKey="Strohecker A" first="Anne M." last="Strohecker">Anne M. Strohecker</name><name sortKey="Williams, Michelle" sort="Williams, Michelle" uniqKey="Williams M" first="Michelle" last="Williams">Michelle Williams</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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